Big Discovery Leads to Treating Leukemia Without Transplantation?

Australian scientists from the children’s research institute “Murdoch” maybe are one step closer to curing leukemia and other blood disorders, after a great progress in the treatment of stem cells.

Researchers at the children’s research institute “Murdoch” managed to create a stem cell in the laboratory, which are almost identical to those that grow in the embryo, says the Australian “News”.

This major discovery could eventually replace bone marrow transplant, and scientists will be able to adapt to a stem cell recipient, in order to reduce the risk of adverse immune reactions.

Trio biologist and researcher – Dr. Elizabeth Ng, a professor Edru Elefanti and Professor Ed Stanley – led the research and study has been published in the journal “Nature Biotechnology”.

“If we can create normal blood stem cells in the laboratory, we can use the same technology to the study of blood diseases such as leukemia and other affecting children and adults,” said Professor Elefanti and added that modeling or re-creation of these diseases in a dish in the laboratory helped to understand what went wrong in such cases and how they can be treated in a better way.

They used the omnipotent stem cells, which can turn into any type of cell in the body, to create blood cells that are very similar to those that develop in the embryo.

Dr Ng explained that the desire of blood that are found in the bone marrow, which originate from the aorta in the development, the main blood vessel of the heart, in the embryo. These cells migrate to the liver of the fetus, which grow for several months before they move into the bone marrow.

The process of developing the cell lasted about two and a half weeks, which is close to the time it takes blood cells to develop into an embryo.

Re-creation of the state of the disease in models of cells means that researchers will be able to test the effects of new drugs and combination treatments, to develop an adaptation of the whole system and, ultimately, to discover ways to control gene expression.

According to Professor Elefante, the focus will be on the observation of blood stem cells in the laboratory to see how they cope with the transplant.

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